Dendritic Cells

Dendritic Cells

We at OLEVRA conduct business under the motto “Helping people achieve better quality of life and healthier living.” Our operations and activities are focused toward immunotherapy using the body’s own dendritic cells. With dendritic cell therapy, OLEVRA taps into the huge potential of individualized immunotherapy, that is, therapy which augments the body’s self-healing capabilities.

How exactly does dendritic cell therapy function?

In dendritic cell therapy or immunotherapy, the cells in the body associated with the body’s resistive forces become dendritic cells that are extracted from the blood of the patient and can be processed by highly specialized methods so that, for example, they can better identify non-body structures and destroy them. With this the dendritic immunotherapy deliberately interferes with the cell’s metabolism and is focused on the individual biomolecular property of the cells. This special method makes dendritic cell therapy more tolerable and more sparing than other methods of treatment. In addition, dendritic cell therapy can be conducted in the outpatient setting.

History of scientific research

Although the immunologist Dr. Ralph Steinman has already suggested that dendritic cells play a decisive role in the activation of the immune system in the 1970s and since then, fundamental scientific research has made great advances, practice-oriented research has only emerged in the late 1990s. Nearly 40 years after the start of Steinman’s research, they have gained recognition from the general public and in a different way; in 2011 he was awarded the Nobel Prize for Medicine, for discoveries related to dendritic cells and their role for the adaptive immunity. Unfortunately, Steinman was unable to accept the prize personally – he died three days before awarding. Today, dendritic immunotherapy is a recognized treatment method for years in Japan and the United States. Moreover, dendritic therapy is used both as a supporting and as a primary therapy in the treatment of cancerous (and other) diseases. However, taking into account the individual condition, the sequence and combination of dendritic cell therapy with other types of treatment is determined.

Dendritic cells – a key role in the immunity

By nature, we have perfect protective forces of our organism – an immune system. Daily it repels penetrating microorganisms, such as bacteria and viruses, but is also capable of recognizing and destroying the improperly functioning cells in the body. Also, cancer cells are detected and destroyed by our immune system. Health professionals assume that certain diseases occur only when, due to genetic factors, or those associated with the environment, our immune system weakens so much that this mechanism of detection, identification, and destruction is hindered.  This is exactly the starting point of dendritic cell therapy. It deals with the immune system and the very interaction of its resistive cells. In addition, dendritic cells have a key role in immune protection as they detect foreign and degenerated cells and tissues and transmit this information to other cells of the immune system that attack and destroy the identified cells. For this reason, dendritic cells are also called guard cells. In addition, dendritic cells take care of the constant flow of information between the cells of the immune system. When dendritic cells detect a pathogenic cell, they decompose it and reproduce antigens (characteristics of the surfaces) of the pathogenic cell on its own cell surface.  So prepared, they migrate to the adjacent lymph nodes and there stimulate the immune defense by presenting T-lymphocyte antigens.  In response to this, they become active in order to further identify other of thus bound cells and to dispose them.  By dendritic cells are activated T helper cells that enter the bloodstream in order to move rapidly to the identified cells. The inflow of other semiochemical substances supports continuous activation of T-lymphocytes and enhances the immune system’s defense response. Finally, the dendritic cells stimulate also the growth of the so-called B-lymphocytes that produce antibodies.